Core Journal Reviews

Filed Under: February 9th, 2024 Leave a Comment
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Diabetic ketoacidosis (DKA) is an endocrine emergency. The  standard of care of treating DKA is fluid resuscitation, electrolyte management, and intravenous insulin infusion in the intensive care unit (ICU) setting for close glucose and electrolyte monitoring. Recent research aims at investigating the treatment of DKA with subcutaneous insulin in non-ICU settings. 

 
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Filed Under: Tags: , February 9th, 2022 Leave a Comment

Prehospital Narrow Pulse Pressure Predicts Need for Resuscitative Thoracotomy and Emergent Intervention After Trauma

Prehospital trauma team activation criteria allow for prompt mobilization of personnel and resources. Prehospital hypotension is one of those criteria. Pulse pressure is the difference between systolic and diastolic blood pressure. This is variously defined as a difference of 30-40 mmHg. A narrow pulse pressure occurs due to compensatory increased systemic vascular resistance in the setting of decreased cardiac output.
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Filed Under: Tags: , January 24th, 2022 Leave a Comment

Validation of Septic Knee Monoarthritis Prediction Rule in a Lyme Disease Endemic Area

Children with knee monoarthritis from Lyme disease and septic arthritis can have similar presentations. The early disseminated stage of Lyme disease, when knee monoarthritis would typically present, occurs 3-5 weeks post tick bite and a history of tick bite may not be present. In addition, synovial fluid cell counts do not distinguish between septic and Lyme arthritis and bacterial cultures and Lyme disease serology may take several days to result.
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Filed Under: Tags: , , , November 22nd, 2021 Leave a Comment

D-Dimer to Rule Out Venous Thromboembolism During Pregnancy: A Systematic Review and Meta-Analysis

Pregnant women have a higher risk of venous thromboembolism (VTE) and an increasing D-Dimer over the course of pregnancy. The majority of clinical guidelines recommend the D-dimer should not be used to assess the risk of VTE in pregnant women. However, CTPE presents a radiation risk to both the mother and fetus. Unfortunately, most VTE studies exclude pregnant women.
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Filed Under: Tags: June 4th, 2021 Leave a Comment

Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial

Acute acidemia is common in critically ill adult patients. Use of sodium bicarbonate infusion for the treatment of severe metabolic acidemia is controversial and understudied.
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