Sensitivity of NCHCT < 6 Hours After Symptom Onset in Suspected SAH

Background

Thanks to Salim Rezaie (@srrezaie) for peer-reviewing this post.

Acute headache is a common emergency department presentation that accounts for 1-2% of all encounters (Goldstein 2006) The differential includes many life-threatening diagnoses, one of which is aneurysmal subarachnoid hemorrhage (SAH). With an estimated overall prevalence of 2% and a 1-month mortality of 40-45%, SAH is a high-risk disease that no emergency physician wants to miss (Linn 1996). 30% of those patients that survive will have severe disabilities (Hop 1997). Rebleeding following initial presentation is the largest cause of death. There is a 1.5% risk of rebleeding per day and a 15-20% risk in the first two weeks (Kassell 1983, Samandouras 2010). Early diagnosis and aneurysm repair using endovascular or surgical treatment before rebleeding occurs improves outcomes. However, about 5% of SAH are misdiagnosed on the first Emergency Department (ED) assessment because up to 50% of SAH patients present with no neurological deficits, providers fail to correctly interpret test results, or providers fail to appreciate the wide spectrum of symptoms that a SAH can present with (Vermeulen 2007, Weir 1994).

The current guidelines put forth by the American Heart / Stroke Association in 2012 state that the acute diagnostic workup for suspected SAH should include a noncontrast head CT (NCHCT), which, if nondiagnostic, should be followed by a lumbar puncture (LP). (Class I; Level B evidence) (Connolly 2012). However, recent studies using modern CT scanners have demonstrated a near 100% sensitivity for detecting SAH if the CT is performed within 6 hours and interpreted by qualified radiologists. This data questions the role of LP after a negative NCHCT when performed within this time window.

Primary Results

Primary Results

• 5 trials included with 8907 patients
• Performed three analyses:
  • “Worst case scenario”: Included patients found to have vascular abnormalities on angiography but unclear if had thunderclap presentation
  • “Intermediate case scenario”: Excluded those with vascular abnormalities but unclear presentations (as above)
  • Three study analysis: Only included articles with direct information in 2 by 2 tables

Critical Findings:

• “Worst Case Scenario”
  • 13 missed SAH (incidence 1.46/1000) on brain CT within 6 hours
  • Sensitivity: 0.987 (95% CI 0.971 – 0.994)
  • Specificity 0.999 (95% CI 0.993 – 1.0)
  • (+) LR: 921.9 (95% CI 139 – 6103)
  • (-) LR :0.010 (95% CI 0.003 – 0.034)
• “Intermediate Case Scenario”
  • 9 missed SAH on brain CT within 6 hours
  • Sensitivity 0.989 (95% CI 0.980 – 0.994)
  • Specificity 1.0 (95% CI 0.993 – 1.0)
• Excluding 2 Studies Without Direct Information
  • incidence of SAH was 19.1%
  • 1/1155 missed SAH (incidence 0.87/1000) on brain CT within 6 hours
  • Sensitivity: 0.986 (95% CI 0.951 – 0.996)
  • Specificity 0.996 (95% CI 0.974 – 0.999)

Strengths

• Extensive literature search performed and a medical librarian was consulted to ensure all relevant articles considered
• Interobserver agreement for article inclusion was high (87.5%)
• Study quality was assessed using the QUADAS-2 tool
• Calculated heterogeneity was low allowing for a composite sensitivity and negative likelihood ratio calculation
• Primary outcomes based on a “worst-case scenario.”

Limitations

• There was significant variation in the incidence of SAH among the studies
• The “gold standard” test for SAH was unevenly applied across all studies
• The studies by Blok and Mark et al, only included patients with negative CTs, so estimations of their true positives and negatives had to be made using the Perry et al study numbers for incidence of 12.7% and the proportion of SAH patients who presented within 6 hours, which was 30%
• All NCHCTs were read by board certified radiologists.
• The Perry study, which contributed the largest number of patients, did not perform LP in all patients. This could lead to missed cases and an overestimation of sensitivity
• Included studies had incidences of SAH that seem higher than what is typically seen in clinical practice

Other Issues

• Headache has a broad differential diagnosis and other dangerous etiologies may not be ruled out simply be performing a NCHCT (i.e. meningitis)

Author's Conclusions

“In patients presenting with thunderclap headache and normal neurological examination, normal brain CT within 6 hours of headache is extremely sensitive in ruling out aneurysmal SAH.”

Our Conclusions

A negative NCHCT performed within 6 hours of onset of headache in a neurologically intact patient with symptoms concerning for SAH has a robust negative likelihood ratio allowing to post-test risk stratify patients to a low enough level where the LP is unlikely to add to the clinical workup. Recent studies (Sayer 2015) looking at the yield of LP should be considered alongside this systematic review and meta-analysis.

Potential Impact To Current Practice

Clinicians can use this information to discuss harms and benefits of additional testing after a negative NCHCT in patients with suspected SAH presenting within 6 hours of symptom onset.

Bottom Line

An LP may not be necessary in patients presenting with suspected SAH who have a negative NCHCT within 6 hours of headache onset.

Read More

EMLitofNote: Is the 6-Hr CT for SAH Debate Over?

ERCast: The Subarachnoid Enigma

St. Emlyn’s Blog: Lets Talk About Subarachnoid Hemorrhage

The SGEM: SGEM #48 – Thunderstruck (Subarachnoid Hemorrhage)

The SGEM: SGEM #134 – Listen, to What the British Doctors Say About LPs Post CT for SAH

REBEL EM:

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